Skenandoah was a prominent Oneida chief best known for switching his allegiance during the American Revolution. He supported the British during the French-Indian War; however, just prior to the American Revolution, he officially declared his tribe's neutral stance - which soon shifted to support for the Americans.

In 1766, Samuel Kirkland, an American missionary, began living with the Oneida. He adopted many of their customs, but at the same time preached Christian ways. He was largely responsible for persuading the Oneida to abandon their neutral stance and support the Americans. Skenandoah, who was a close personal friend to Samuel Kirkland, began sending some warriors to help the Americans. When George Washington's men were starving at Valley Forge, Skenandoah sent baskets of corn. Skenandoah also informed residents of German Flats, New York, that Joseph Brant and the British Loyalists were going to raid their town. The settlers were able to save themselves, but lost all their property and possessions. In recognition of Skenandoah's invaluable support, George Washington named the Shenandoah Valley after him.

Following the American Revolution, Skenandoah remained the principal chief of the Oneida. In 1816, Skenandoah died. Per his request, he was buried next to Samuel Kirkland at Hamilton College cemetery in Clinton, New York.